Endocrine Abstracts

Introduction: In humans, Cushing’s syndrome (CS) is associated with an increased incidence of the metabolic syndrome, increased cardiovascular morbidity and mortality, even after long-term correction of glucocorticoid (GC) excess.Aim: To evaluate the effects of transient overexposure to GC on the metabolic changes in the long-term in mice.Methods: Single housed male C57Bl/6J mice were given corticosterone (CORT; 50 μg/ml)...

Context and objective: Coping strategies may affect quality of life (QoL), which is decreased in patients after treatment for Cushing’s disease, acromegaly, or non-functioning macroadenomas (NFMA). We aimed to explore coping strategies in these patients, since this has never been done before.Design: A cross sectional study.Subjects: We included patients treated for Cushing’s disease (n=42), for acromegaly (n...

Context and objective: Illness perceptions pertain the pattern of beliefs patients develop about their illness. These views are determinants of behavior directed at the illness. Illness perceptions are determinants of quality of life (QoL). QoL remains impaired in patients after treatment of endogenous hypercortisolism, however, illness perceptions were never studied in these patients. The objective of the current study was to explore illness perceptions and its relation with ...

Context: Recombinant human GH (rhGH) is indicated for the treatment of adult subjects with GH deficiency (GHD). However, conflicting data are available on the efficacy of rhGH treatment in elderly GHD patients.Objective: To assess the efficacy of rhGH treatment in elderly GHD subjects.Methods: We searched PubMed, Cochrane Library, Web of Science, and EMBASE.Study selection: Eligible studies included GHD patie...

Introduction: Persistent hyperparathyroidism is reported to occur in 0–6% of cases after initial surgery for sporadic primary hyperparathyroidism (PHPT). The management of these cases is complex, however, with a poor cure rate despite repeated surgery. The aim of our study was to identify the challenges and pitfalls encountered in the management of a series of patients with persistent hyperparathyroidism after initial parathyroidectomy.Patients and ...

Objective: The aim of the present study was to determine whether insulin resistance is important in well controlled, uncomplicated patients with type 1 diabetes on long term CSII, compared to matched healthy controls.Research design and methods: We studied 8 patients (4 men and 4 women) with type 1 diabetes on stable continuous subcutaneous insulin pump therapy and 8 healthy controls, matched for age, gender and BMI. Insulin sensitivity was measured by h...

Background: Human sleep is composed of different sleep stages, of which slow wave sleep (SWS) is an important modulator of glucose regulation. Curtailment of sleep duration in general and of slow wave sleep (SWS) in particular reduces glucose tolerance in healthy subjects. Previously, we have reported that a single night of partial sleep deprivation reduces insulin sensitivity by 15–20% in patients with type 1 diabetes. We hypothesized that this effect could be a conseque...

Background: Patients suffering from polycystic ovarian syndrome (PCOS) are warned for arterial disease. We examined the risk of (non)fatal coronary heart disease (CHD) or stroke between PCOS patients and ovulatory, non-PCOS women. Further we assessed the effect of obesity on this riskMethods: We performed a systematic review and meta-analysis of controlled observational studies. Four definitions of PCOS were considered: WHO type II anovulation (1976), NI...

Background: The long-term prevalence of adrenal insufficiency after transsphenoidal surgery for GH secreting pituitary adenomas was unknown. However, recently a single study reported a high prevalence of adrenal insufficiency after surgical and/or medical treatment without postoperative radiotherapy in acromegalic patients.Aim: To assess the prevalence and incidence rate of adrenal insufficiency in consecutive patients during long-term follow-up after su...

Introduction: Sleep restriction and/or impaired sleep quality negatively influence glucoregulation. The aim of this study was to assess subjective sleep parameters in patients with type 1 diabetes, to relate sleep parameters to long-term glycaemic control, and to assess possible risk factors for impaired sleep.Research design and methods: We studied 99 adult patients with type 1 diabetes (55M, 44F, duration of diabetes 26.9±1.2 years) and 99 age-, g...